DMT 101

What is DMT?

DMT is a naturally-occurring psychedelic alkaloid derived from the amino acid tryptophan. Although it lacks the popularity of its longer-acting relatives, DMT is the most commonly-occurring psychedelic compound, and is found in small quantities in many plants and animals -including humans!

The experience induced by DMT is the second most intense of any psychedelic, shattering the user's idea of reality before safely returning them to their sober mind in just 15-30 minutes.

Despite its scheduling, DMT is not an addictive or hazardous drug. Its consumption has never been attributed to a death, it does not carry any other substantial physical risk, and it is not habit-forming.


The DMT Experience

The DMT experience is usually divided into 4 levels, each with drastically different effects.

  1. Low Dose:

The experience in this range typically resemble those of DMT's longer-acting structural relatives, and includes effects such as:

    1. Increased brightness and saturation of vision

    2. Visual distortions

    3. Geometric patterning

    4. Light psychedelic headspace


  1. Medium Dose:

At medium doses, the DMT experience begins to diverge from those of other psychedelics into the unique trip offered only by this compound, and induces effects including:

  1. Simplification of objects

  2. Powerful body load

  3. Extreme geometric overlay

  4. Entering "The Waiting Room"


  1. Breakthrough Dose:

Doses this high generate the "signature" DMT trip, which often include the following effects:

  1. The sensation of being propelled from one's body

  2. Entering DMT "hyperspace"

  3. Sensations of godly presence

  4. Meeting entities that seem independent from one's own consciousness, including:

    1. Elves

    2. Jesters

    3. Gods

    4. Angels

    5. Demons

    6. Aliens


  1. Blackout:

Excessively high doses of DMT will result in a temporary blackout. Those who experience blackouts have no memory of the experience and often return confused due to the lost time. It is not recommended that anyone attempt extremely high doses, especially using a very efficient method of consumption

Identification

The identification of DMT can seem tricky given the number of colors it appears in. These are caused either by the presence of harmless plant fats coating the crystals or the different ways the compound orients itself to form the crystal lattices. The compound has a distinctive smell of mothballs, flowers, new shoes, or plastic. While this many descriptors sounds vague, the smell is instantly distinguishable from almost any other and is unique to indole-derived drugs. If one's sample of DMT appears dark purple or brown it must be re-crystallized prior to consumption. Very dark coloration may indicate the presence of sodium hydroxide (caustic soda/drain cleaner) in the sample.

There is very little incentive to sell another drug in DMT's place as it has one of the highest profit margins of any drug selling for as much as $400/g in 2022 while costing 10x less to produce -even in very small quantities. Despite this, testing one's sample prior to consumption is important to determine if it is safe to consume.

Methods of Consumption

DMT is unique among the classical psychedelics in the wide variety of methods by which users partake of the compound. Though their efficiencies vary drastically, the goal is often the same: to induce the most powerful and visionary psychedelic experience one can handle.

  1. Marijuana: Adding DMT to marijuana will intensify the experience, but is not often recommended. This is because it becomes far easier to burn the compound on the embers and the user will be high following their DMT experience, which can lead to anxiety.

  2. Changa: Mixing DMT with an MAOI (monoamine oxidase inhibitor) containing plant will cause the experience to increase in both intensity and duration. However, as with marijuana, this method increases the likelihood of burning one's DMT through direct contact with the flame or embers.

  3. Oil Pipe: This is the most common method by which DMT is consumed, likely due to the pipe's use with other freebase crystalline drugs. It is not particularly efficient, but effective enough to achieve breakthrough on DMT alone.

  4. The Machine: A homemade pipe for DMT created by drilling a hole in the bottom of a bottle and plugging the neck with steel wool.

  5. E-Liquid: Mixing a 1:1 ratio of DMT to propylene glycol will result in a potent e-liquid that can be used in any concentrate vaporizer. The efficiency of this method largely depends on the device used, although it lags behind others as the cartridges can become burnt or inundated with oils and lower its effectiveness.

  6. Vapor Genie: The vapor genie is a pipe designed specifically for DMT and is capable of reaching 100% efficiency with relative ease.

  7. Dab Rig: Assuming the proper temperature is achieved, vaporizing DMT with a dab rig is 100% efficient and has the added benefit of delivering the entire dose at once.

  8. Ayahuasca: While ayahuasca's efficiency is technically limited by the bioavailability of DMT through ingestion, the MAOI

  9. E-Mesh: Once set to the proper temperature, a direct E-mesh will vaporize an entire dose of DMT with 100% efficiency every time it is used, without any effort on the user's part.

  10. Injection: Used only by researchers, injecting the DMT allows for complete control over the dose and the duration over which it is administered to accurately reach a target blood concentration for the necessary period of time.

Dab Rig Vaporization

Duration of Action

The duration of a DMT experience is primarily dependent on the presence or absence of an MAOI (MonoAmine Oxidase Inhibitor). These compounds have the ability to block the action of the monoamine oxidase enzyme responsible for converting DMT to an inactive form. With the enzyme's function inhibited, the DMT will remain active for an extended duration and lengthen the trip.

In the case of vaporized freebase, the experience typically lasts up to 30 minutes total, with effects peaking towards the beginning of the experience. A changa-induced trip has a similar timeline applied over a longer duration. Though it is depicted as less potent due to the method's lack of efficiency, a changa experience induced by an identical active dose of DMT will be of similar intensity and an extended duration. Ayahuasca experiences are of a much longer duration.

Safety

As the compound itself has an impossibly high LD-50, the physical safety of DMT use is almost entirely dependent on its proper consumption.

Hazards include:

1. Dropping hot glass on oneself

2. Falling down if smoked while standing

3. Throat or lung irritation

4. Gastrointestinal irritation

5. Serotonin syndrome or death if ayahuasca is taken alongside interactive medication

These hazards can all be avoided by using proper smoking technique, the presence of a sitter, thorough research, and following a rigid set and setting protocol.

Extraction

DMT extraction is hazardous and illegal. It must never be attempted by anyone but trained chemists in a government-approved research setting.

DMT is extracted from plant material -most often the root bark of Mimosa hostilis- using the acid-base extraction technique. This method of extraction takes advantage of the changing solubility of the desired compound based on pH. It is conducted as follows:

  1. The sample is dried and ground into a fine powder

  2. The sample is added to a beaker, acidified to a pH of 3, and given time to extract the alkaloids from the plant material.

  3. The material is then filtered out and the resulting solution is added to a collection vessel. A concentrated solution of NaOH is added dropwise to the solution until the pH reaches or exceeds 12.

  4. A final liquid-liquid extraction is performed using a nonpolar solvent to remove freebase DMT from the aqueous solution.

  5. A separatory funnel is used to separate the upper nonpolar layer from the denser aqueous layer. This step is repeated to maximize yeild.

  6. The resulting nonpolar solution is added to a large, flat disk or placed in a freezer at -20 C to form crystals of freebase DMT.

  7. If the purity is determined to be lower than desired, the DMT is redissolved in fresh nonpolar solvent and recrystallized using freeze-precipitation.

  8. Once the desired purity is acheived, the % yield of the extraction is calculated using the following formula:

%Yield = Mass of final yield / Mass of plant matter

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This poster contains all of the essential information on DMT's identification, safe use, and the experience it induces